The Absolutely True Diary of a Part-Time Indian explores human issues such as depression. The first issue is low self-esteem which reservations have counselors for, “Yep, I belong to the Black-Eye-of-The-Month-Club” pg 4. Another issue deals with employment, “what kind of job can a reservation Indian boy get” pg10. Both of these issues contribute to Junior’s low-self esteem in relation to his health problems. Junior’s lack of motivation leads to depression. “I wish I were magical, but I am really just a poor-ass reservation kid living with his poor-ass family on the poor-ass Spokane Indian Reservation” pg 7.These human issues, low self-esteem and employment, contribute to Juniors depression, yet fires his ambition to succeed.